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Compound Detail

CHEMBL5078989

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Cc1ccc(/N=N/c2ccc(OCCc3ccc(OC(C)(C)C(=O)O)cc3)c(C)c2)cc1

Basic Information

ChEMBL ID CHEMBL5078989
Phase Preclinical
Structure Type MOL
InChI Key ZYPQJZCZDBGRGN-BYYHNAKLSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

432.5
MW (Da)
6.58
ALogP
5
HBA
1
HBD
80.5
PSA (Ų)
0.39
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H28N2O4
MW 432.52
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -0.56

Activity Summary

EC50 3 meas. best 7.44

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Peroxisome proliferator-activated receptor alpha
CHEMBL239
EC50 7.44 7.44 36.0 1
Peroxisome proliferator-activated receptor delta
CHEMBL3979
EC50 6.92 6.92 120.0 1
Peroxisome proliferator-activated receptor gamma
CHEMBL235
EC50 5.64 5.64 2300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
34213899 10.1021/acs.jmedchem.1c00810 Peroxisome proliferator-activated receptor delta 2
34213899 10.1021/acs.jmedchem.1c00810 Peroxisome proliferator-activated receptor gamma 2
34213899 10.1021/acs.jmedchem.1c00810 Peroxisome proliferator-activated receptor alpha 2

Data from ChEMBL 36 via Core Engine