Compound Detail

CHEMBL5077927

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Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CC(F)F

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL5077927
Phase	Preclinical
Structure Type	MOL
InChI Key	JQVRJDHSZIESJC-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

304.3

MW (Da)

2.23

ALogP

HBA

HBD

95.6

PSA (Å²)

0.77

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

IC50 4 meas. best 8.52

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292	IC50	8.52	7.995	3.0	2
Dual specificity tyrosine-phosphorylation-regulated kinase 2 CHEMBL4376	IC50	8.4	8.4	4.0	1
Cyclin-dependent kinase 9 CHEMBL3116	IC50	5.25	5.25	5692.0	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	IC50	=	3.0	nM	8.52	Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as c...	33975430
Dual specificity tyrosine-phosphorylation-regulated kinase 2	IC50	=	4.0	nM	8.4	Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co...	33975430
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	IC50	=	34.0	nM	7.47	Inhibition of wild type full length DYRK1A (unknown origin) in human U2OS cells ...	33975430
Cyclin-dependent kinase 9	IC50	=	5692.0	nM	5.25	Inhibition of CDK9 (unknown origin) using Ulight-MBP as substrate and ATP as co-...	33975430

PubMed	DOI	Target Context	# Activities
33975430	10.1021/acs.jmedchem.1c00023	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	2
33975430	10.1021/acs.jmedchem.1c00023	Cyclin-dependent kinase 9	1
33975430	10.1021/acs.jmedchem.1c00023	Dual specificity tyrosine-phosphorylation-regulated kinase 2	1

Data from ChEMBL 36 via Core Engine