Compound Detail
CHEMBL5080177
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C=CC(=O)N1CCN(CCCCCn2nc(-c3ccc(OCc4ccccc4)cc3)c3c(N)ncnc32)CC1
Basic Information
| ChEMBL ID | CHEMBL5080177 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BEAMZXDHWORNKL-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
525.7
MW (Da)
4.16
ALogP
8
HBA
1
HBD
102.4
PSA (Ų)
0.23
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 5.82 | 5.82 | 1501.0 | 1 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 5.63 | 5.63 | 2345.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 1501.0 | nM | 5.82 | Inhibition of human FGFR1 (459 to 765 residues) expressed in Escherichia coli BL... | 34129329 |
| Fibroblast growth factor receptor 2 | IC50 | = | 2345.0 | nM | 5.63 | Inhibition of human FGFR2 (458 to 768 residues) expressed in Escherichia coli BL... | 34129329 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34129329 | 10.1021/acs.jmedchem.1c00174 | Fibroblast growth factor receptor 1 | 1 |
| 34129329 | 10.1021/acs.jmedchem.1c00174 | Fibroblast growth factor receptor 2 | 1 |
| 34129329 | 10.1021/acs.jmedchem.1c00174 | Fibroblast growth factor receptor 3 | 1 |
| 34129329 | 10.1021/acs.jmedchem.1c00174 | Fibroblast growth factor receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine