Compound Detail
CHEMBL5084840
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COc1cc(OC)cc(-c2nn(CCCCCN3CCN(C(=O)/C=C/CN(C)C)CC3)c3ncnc(N)c23)c1
Basic Information
| ChEMBL ID | CHEMBL5084840 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AFGXVTXVCTUMNA-CMDGGOBGSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
536.7
MW (Da)
2.53
ALogP
10
HBA
1
HBD
114.9
PSA (Ų)
0.28
QED
1
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.86
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.86 | 7.86 | 13.8 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 7.81 | 7.81 | 15.5 | 1 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 7.43 | 7.43 | 37.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 13.8 | nM | 7.86 | Inhibition of human FGFR1 (459 to 765 residues) expressed in Escherichia coli BL... | 34129329 |
| Fibroblast growth factor receptor 3 | IC50 | = | 15.5 | nM | 7.81 | Inhibition of human FGFR3 (450 to 758 residues) expressed in Escherichia coli BL... | 34129329 |
| Fibroblast growth factor receptor 2 | IC50 | = | 37.5 | nM | 7.43 | Inhibition of human FGFR2 (458 to 768 residues) expressed in Escherichia coli BL... | 34129329 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34129329 | 10.1021/acs.jmedchem.1c00174 | Fibroblast growth factor receptor 1 | 1 |
| 34129329 | 10.1021/acs.jmedchem.1c00174 | Fibroblast growth factor receptor 2 | 1 |
| 34129329 | 10.1021/acs.jmedchem.1c00174 | Fibroblast growth factor receptor 3 | 1 |
| 34129329 | 10.1021/acs.jmedchem.1c00174 | Fibroblast growth factor receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine