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Compound Detail

CHEMBL5085869

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Cc1ccc2c(c1)-n1c(nnc1[C@H]1CC[C@H](Oc3ccccn3)CC1)CC(O)C2

Basic Information

ChEMBL ID CHEMBL5085869
Phase Preclinical
Structure Type MOL
InChI Key DDCXBLIOHUHHNV-KKLGJNPISA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

390.5
MW (Da)
3.54
ALogP
6
HBA
1
HBD
73.1
PSA (Ų)
0.74
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H26N4O2
MW 390.49
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -0.84

Activity Summary

IC50 1 meas. best 6.41
Ki 1 meas. best 7.47

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vasopressin V1a receptor
CHEMBL1889
Ki 7.47 7.47 34.0 1
Vasopressin V1a receptor
CHEMBL1889
IC50 6.41 6.41 390.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
34255509 10.1021/acs.jmedchem.1c00863 Vasopressin V1a receptor 2
34255509 10.1021/acs.jmedchem.1c00863 Vasopressin V2 receptor 1

Data from ChEMBL 36 via Core Engine