Compound Detail
CHEMBL5091221
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CN(CCCNC(=O)OC(C)(C)C)C(=O)c1ccc2cc(CCNc3ccnc4ccc(C#N)cc34)ccc2c1
Basic Information
| ChEMBL ID | CHEMBL5091221 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WSHKPIHTYDQNDK-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
537.7
MW (Da)
5.90
ALogP
6
HBA
2
HBD
107.3
PSA (Ų)
0.26
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| CDK8/Cyclin C CHEMBL3038474 | IC50 | 8.03 | 8.03 | 9.3 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.76 | 6.72 | 173.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| CDK8/Cyclin C | IC50 | = | 9.3 | nM | 8.03 | Inhibition of kinase tracer 236 binding to His tagged recombinant human CDK8/cyc... | 35114084 |
| Unchecked | IC50 | = | 173.0 | nM | 6.76 | Inhibition of CDK8/CDK19 in MV4-11 cells and measured after 7 days by Spectra ma... | 35114084 |
| Unchecked | IC50 | = | 208.0 | nM | 6.68 | Inhibition of NF kappa B dependent CDK8/CDK19 in HEK293 cell incubated for 3 hrs... | 35114084 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35114084 | 10.1021/acs.jmedchem.1c01951 | Unchecked | 2 |
| 35114084 | 10.1021/acs.jmedchem.1c01951 | CDK8/Cyclin C | 1 |
Data from ChEMBL 36 via Core Engine