Compound Detail
CHEMBL5092423
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Basic Information
| ChEMBL ID | CHEMBL5092423 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DNCBJIHODDSWSH-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
346.4
MW (Da)
2.76
ALogP
6
HBA
3
HBD
111.8
PSA (Ų)
0.53
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.86
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NOMO-1 CHEMBL2366198 | IC50 | 8.86 | 8.86 | 1.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NOMO-1 | IC50 | = | 1.396 | nM | 8.86 | Antiproliferative activity against human NOMO-1 cells after 72 hrs by MTT assay | - |
| NOMO-1 | IC50 | = | 1.39 | nM | 8.86 | Antiproliferative activity against human NOMO-1 cells assessed as reduction in c... | 39150226 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39150226 | 10.1021/acs.jmedchem.4c01247 | NOMO-1 | 1 |
Data from ChEMBL 36 via Core Engine