Assay Detail
Functional
CHEMBL5587775
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Antiproliferative activity against human NOMO-1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NOMO-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Methyl-Transferase-Like Protein 16 (METTL16): The Intriguing Journey of a Key Epitranscriptomic Player Becoming an Emerging Biological Target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.75 | 8.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5092423 | — | — | 1 | 8.86 |
| CHEMBL525284 | — | — | 1 | 8.81 |
| CHEMBL526243 | — | — | 1 | 7.69 |
| CHEMBL5078515 | — | — | 1 | 7.26 |
| CHEMBL5090829 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5092423 | — | IC50 | = | 1.39 | nM | 8.86 |
| CHEMBL525284 | — | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL526243 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL5078515 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5090829 | — | IC50 | = | 736.0 | nM | 6.13 |