Compound Detail
CHEMBL525284
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL525284 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IKTNEAXAJOAXRM-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
323.8
MW (Da)
3.45
ALogP
5
HBA
2
HBD
82.8
PSA (Ų)
0.59
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.81
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NOMO-1 CHEMBL2366198 | IC50 | 8.81 | 8.81 | 1.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NOMO-1 | IC50 | = | 1.55 | nM | 8.81 | Antiproliferative activity against human NOMO-1 cells after 72 hrs by MTT assay | - |
| NOMO-1 | IC50 | = | 1.55 | nM | 8.81 | Antiproliferative activity against human NOMO-1 cells assessed as reduction in c... | 39150226 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20485427 | 10.1038/nature09107 | Plasmodium falciparum | 4 |
| 20485427 | 10.1038/nature09107 | Unchecked | 1 |
| 20485427 | 10.1038/nature09107 | HepG2 | 1 |
| 39150226 | 10.1021/acs.jmedchem.4c01247 | NOMO-1 | 1 |
Data from ChEMBL 36 via Core Engine