Compound Detail
CHEMBL509541
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Basic Information
| ChEMBL ID | CHEMBL509541 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UVZITGSILYMIFF-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
3
PK Parameters
2
Publications
0
Known Names
Molecular Properties
232.3
MW (Da)
1.49
ALogP
4
HBA
2
HBD
83.1
PSA (Ų)
0.84
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hydroxycarboxylic acid receptor 2 CHEMBL4420 | IC50 | 7.22 | 6.95 | 60.0 | 2 |
| Hydroxycarboxylic acid receptor 2 CHEMBL3785 | IC50 | 7.1 | 6.785 | 80.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 21.0 | mL.min-1.kg-1 | Mus musculus |
| F | 34.0 | % | Mus musculus |
| T1/2 | 1.5 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hydroxycarboxylic acid receptor 2 | IC50 | = | 60.0 | nM | 7.22 | Displacement of [3H]nicotinic acid from mouse GPR109a receptor | 19307116 |
| Hydroxycarboxylic acid receptor 2 | IC50 | = | 80.0 | nM | 7.1 | Displacement of [3H]nicotinic acid from human GPR109a receptor | 19307116 |
| Hydroxycarboxylic acid receptor 2 | IC50 | = | 210.0 | nM | 6.68 | Displacement of [3H]nicotinic acid from mouse GPR109a receptor | 19307116 |
| Hydroxycarboxylic acid receptor 2 | IC50 | = | 340.0 | nM | 6.47 | Displacement of [3H]nicotinic acid from human GPR109a receptor | 19307116 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19307116 | 10.1016/j.bmcl.2009.03.014 | Hydroxycarboxylic acid receptor 2 | 4 |
| 19307116 | 10.1016/j.bmcl.2009.03.014 | Mus musculus | 4 |
Data from ChEMBL 36 via Core Engine