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Target Snapshot

CHEMBL4420 Target Snapshot

Hydroxycarboxylic acid receptor 2 · SINGLE PROTEIN · Mus musculus

83Compounds
14Assays
2Approved Drugs
59.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9EP66. Use UniProt Q9EP66 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9EP66 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Hydroxycarboxylic acid receptor 2 as ChEMBL target CHEMBL4420, mapped to UniProt Q9EP66. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Hydroxycarboxylic acid receptor 2
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4420
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9EP66
Hydroxycarboxylic acid receptor 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Hydroxycarboxylic acid receptor 2 is the right protein anchor across sources, using UniProt Q9EP66 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHydroxycarboxylic acid receptor 2
UniProt AccessionQ9EP66
Component TypeProtein
Sequence Length360 aa

Hydroxycarboxylic acid receptor 2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Hydroxycarboxylic acid receptor 2, mapped to UniProt Q9EP66. Sequence length is 360 aa.

Mapped IDQ9EP66
Review nameHydroxycarboxylic acid receptor 2
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5042.0
EC5017.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1671877 8.4 EC50 4.0 Preclinical
CHEMBL2036954 8.4 EC50 4.0 Preclinical
CHEMBL2036951 8.3 EC50 5.0 Preclinical
CHEMBL2036958 8.22 EC50 6.0 Clinical
CHEMBL2036813 7.92 EC50 12.0 Preclinical
CHEMBL1672639 7.82 EC50 15.0 Preclinical
CHEMBL573 7.54 EC50 29.0 Approved
CHEMBL1208923 7.52 IC50 30.0 Preclinical
CHEMBL520137 7.4 IC50 40.0 Preclinical
CHEMBL509541 7.22 IC50 60.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
11
5.5
9
6.0
12
6.5
8
7.0
5
7.5
4
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

NIACIN
CHEMBL573
Approved 1982
Assay Landscape

Assay Landscape

14
Total Assays
36
Tested Compounds
2
Assay Types
Functional — 11 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 9 12 7.2
single protein format 2 1 6.4
Binding — 3 assays, 36 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 3 36 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine