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Compound Detail

CHEMBL509729

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O=C(O)c1cc(NC2CCCCC2)cc(Oc2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)c1

Basic Information

ChEMBL ID CHEMBL509729
Phase Preclinical
Structure Type MOL
InChI Key VEUGQXGAUFVVAZ-YZNIXAGQSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

535.1
MW (Da)
6.76
ALogP
5
HBA
4
HBD
90.8
PSA (Ų)
0.24
QED
2
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H35ClN2O4
MW 535.08
Aromatic Rings 3
Heavy Atoms 38
NP-Likeness -0.65

Activity Summary

EC50 2 meas. best 9.11

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 9.11 9.11 0.8 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 7.16 7.16 69.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18651730 10.1021/jm800222k Beta-3 adrenergic receptor 2
18651730 10.1021/jm800222k Canis familiaris 2
18651730 10.1021/jm800222k Beta-1 adrenergic receptor 1
18651730 10.1021/jm800222k Unchecked 1
18651730 10.1021/jm800222k Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine