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Compound Detail

CHEMBL513378

PESTALACHLORIDE B
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CC(C)=CCc1c(O)cc(O)c2c1C(=O)c1c(O)c(Cl)c(C)c(Cl)c1OC2

Basic Information

ChEMBL ID CHEMBL513378
Name PESTALACHLORIDE B
Phase Preclinical
Structure Type MOL
InChI Key XCFFTGALQWABRD-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

409.3
MW (Da)
5.05
ALogP
5
HBA
3
HBD
87.0
PSA (Ų)
0.60
QED
1
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C20H18Cl2O5
MW 409.27
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness 1.64

Activity Summary

IC50 3 meas. best 5.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Fusarium graminearum
CHEMBL2366834
IC50 5.96 5.96 1100.0 1
Fusarium culmorum
CHEMBL612752
IC50 5.33 5.33 4700.0 1
Verticillium albo-atrum
CHEMBL613171
IC50 5.1 5.1 7900.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18694644 10.1016/j.bmc.2008.07.075 Fusarium culmorum 2
18694644 10.1016/j.bmc.2008.07.075 Fusarium graminearum 2
18694644 10.1016/j.bmc.2008.07.075 Verticillium albo-atrum 2
31829592 10.1021/acs.jnatprod.9b00646 PANC-1 1

Data from ChEMBL 36 via Core Engine