Compound Detail
CHEMBL517023
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Basic Information
| ChEMBL ID | CHEMBL517023 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MCRXCVLKEGSZPJ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
338.4
MW (Da)
1.98
ALogP
6
HBA
3
HBD
100.3
PSA (Ų)
0.66
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Calcium-activated potassium channel subunit alpha-1 CHEMBL5505 | IC50 | 4.66 | 4.66 | 21877.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Calcium-activated potassium channel subunit alpha-1 | IC50 | = | 21877.62 | nM | 4.66 | Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of ... | 18400336 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18400336 | 10.1016/j.ejmech.2008.02.032 | Calcium-activated potassium channel subunit alpha-1 | 2 |
Data from ChEMBL 36 via Core Engine