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Target Snapshot

CHEMBL5505 Target Snapshot

Calcium-activated potassium channel subunit alpha-1 · SINGLE PROTEIN · Rattus norvegicus

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73Compounds
25Assays
0Approved Drugs
17.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q62976. Use UniProt Q62976 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q62976 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Calcium-activated potassium channel subunit alpha-1 as ChEMBL target CHEMBL5505, mapped to UniProt Q62976. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Calcium-activated potassium channel subunit alpha-1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL5505
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q62976
Calcium-activated potassium channel subunit alpha-1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Calcium-activated potassium channel subunit alpha-1 is the right protein anchor across sources, using UniProt Q62976 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameCalcium-activated potassium channel subunit alpha-1
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtQ62976
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCalcium-activated potassium channel subunit alpha-1
UniProt AccessionQ62976
Component TypeProtein
Sequence Length1209 aa

Calcium-activated potassium channel subunit alpha-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Calcium-activated potassium channel subunit alpha-1, mapped to UniProt Q62976. Sequence length is 1209 aa.

Mapped IDQ62976
Review nameCalcium-activated potassium channel subunit alpha-1
OrganismRattus norvegicus
Assay Mix

Activity Type Distribution

IC5017.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL496460 7.4 IC50 39.81 Preclinical
CHEMBL498516 6.21 IC50 616.6 Preclinical
CHEMBL384903 5.36 IC50 4365.16 Preclinical
CHEMBL498702 5.2 IC50 6309.57 Preclinical
CHEMBL525555 4.8 IC50 15848.93 Preclinical
CHEMBL511502 4.75 IC50 17782.79 Preclinical
CHEMBL454860 4.74 IC50 18197.01 Preclinical
CHEMBL455120 4.7 IC50 19952.62 Preclinical
CHEMBL511864 4.69 IC50 20417.38 Preclinical
CHEMBL517023 4.66 IC50 21877.62 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
0
5.5
1
6.0
0
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

25
Total Assays
16
Tested Compounds
1
Assay Types
Binding — 25 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 17 0 —
tissue-based format 6 9 4.8
single protein format 2 7 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine