Compound Detail
CHEMBL496460
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Basic Information
| ChEMBL ID | CHEMBL496460 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CRMXYFHXROCNSR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
418.2
MW (Da)
5.26
ALogP
3
HBA
1
HBD
38.3
PSA (Ų)
0.72
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Calcium-activated potassium channel subunit alpha-1 CHEMBL5505 | IC50 | 7.4 | 7.4 | 39.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Calcium-activated potassium channel subunit alpha-1 | IC50 | = | 39.81 | nM | 7.4 | Activation of large-conductance calcium-activated potassium channel-mediated vas... | 18680269 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18680269 | 10.1021/jm701605f | Calcium-activated potassium channel subunit alpha-1 | 4 |
Data from ChEMBL 36 via Core Engine