Compound Detail
CHEMBL525555
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Basic Information
| ChEMBL ID | CHEMBL525555 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MUKCXAYOUMEGBK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
350.2
MW (Da)
4.24
ALogP
3
HBA
1
HBD
38.3
PSA (Ų)
0.88
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Calcium-activated potassium channel subunit alpha-1 CHEMBL5505 | IC50 | 4.8 | 4.8 | 15848.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Calcium-activated potassium channel subunit alpha-1 | IC50 | = | 15848.93 | nM | 4.8 | Activation of large-conductance calcium-activated potassium channel-mediated vas... | 18680269 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18680269 | 10.1021/jm701605f | Calcium-activated potassium channel subunit alpha-1 | 2 |
Data from ChEMBL 36 via Core Engine