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Compound Detail

CHEMBL5170587

VK5211
🧪 Phase II
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🧪 Phase II
N#Cc1ccc(N2CCC[C@@H]2[C@@H](O)C(F)(F)F)cc1C(F)(F)F
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL5170587
Name VK5211
Phase Phase II
Structure Type MOL
InChI Key OPSIVAKKLQRWKC-VXGBXAGGSA-N

Known Names

LGD-4033 Ligandrol Vk 5211 Vk-5211 Vk5211
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
5
Known Names
1
Indications
1
Mechanisms

Molecular Properties

338.2
MW (Da)
3.47
ALogP
3
HBA
1
HBD
47.3
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer

Extended Properties

Molecular Formula C14H12F6N2O
MW 338.25
Aromatic Rings 1
Heavy Atoms 23
NP-Likeness -0.75

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Androgen Receptor modulator MODULATOR Androgen receptor ✓ ✓

Indications

Hip Fractures

Activity Summary

Ki 1 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Androgen receptor
CHEMBL1871
 Ki 9.0 9.0 1.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Androgen receptor Ki = 1.0 nM 9.0 Binding affinity to human Androgen receptor 35786895

Literature References

PubMed DOI Target Context # Activities
35786895 10.1021/acs.jmedchem.2c00716 Androgen receptor 1

Data from ChEMBL 36 via Core Engine