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Compound Detail

CHEMBL5176681

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COc1ccc(CNC(CO)c2cc(F)c(N)c(Br)c2)cc1.Cl

Basic Information

ChEMBL ID CHEMBL5176681
Phase Preclinical
Structure Type MOL
InChI Key KPRKMSGIFMGJCY-UHFFFAOYSA-N
Parent Compound CHEMBL5221722
Active Moiety CHEMBL5221722
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

369.2
MW (Da)
3.00
ALogP
4
HBA
3
HBD
67.5
PSA (Ų)
0.69
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H19BrClFN2O2
MW 405.70
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.73

Activity Summary

EC50 1 meas. best 5.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 5.0 5.0 10000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
35360904 10.1021/acs.jmedchem.1c02006 Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine