Compound Detail
CHEMBL5176926
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Basic Information
| ChEMBL ID | CHEMBL5176926 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HSAIDXNOFNJTBF-GKTGUEEDSA-N |
| Parent Compound | CHEMBL4077165 |
| Active Moiety | CHEMBL4077165 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
304.3
MW (Da)
4.54
ALogP
4
HBA
2
HBD
45.1
PSA (Ų)
0.75
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Advanced glycosylation end product-specific receptor CHEMBL2176846 | Kd | 9.0 | 9.0 | 1.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Advanced glycosylation end product-specific receptor | Kd | = | 1.0 | nM | 9.0 | Binding affinity to RAGE (unknown origin) assessed as dissociation constant | 34905377 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34905377 | 10.1021/acs.jmedchem.1c01571 | Advanced glycosylation end product-specific receptor | 1 |
| 34905377 | 10.1021/acs.jmedchem.1c01571 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine