Compound Detail
CHEMBL5177469
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5177469 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HLHNFJNSQZZUNW-MAEOIBBWSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
18
Publications
0
Known Names
Molecular Properties
401.5
MW (Da)
3.98
ALogP
3
HBA
4
HBD
85.6
PSA (Ų)
0.39
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 7.1
IC50 1 meas. best 5.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucose-induced degradation protein 4 homolog CHEMBL5169174 | Kd | 7.1 | 7.095 | 80.0 | 2 |
| Glucose-induced degradation protein 4 homolog CHEMBL5169174 | IC50 | 5.39 | 5.39 | 4100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucose-induced degradation protein 4 homolog | Kd | = | 80.0 | nM | 7.1 | Binding affinity to GID4 (unknown origin) assessed as dissociation constant by s... | 36117290 |
| Glucose-induced degradation protein 4 homolog | Kd | = | 81.0 | nM | 7.09 | Binding affinity to recombinant GID4 (unknown origin) assessed as dissociation c... | 38516600 |
| Glucose-induced degradation protein 4 homolog | IC50 | = | 4100.0 | nM | 5.39 | Inhibition of GID4 (124 to 289) (unknown origin) expressed in Escherichia coli B... | 36117290 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL5724558 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL5674860 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL5303304 | Fibroblast | 7 |
| - | 10.6019/CHEMBL5303304 | HEK-293T | 6 |
| - | 10.6019/CHEMBL5608141 | Colon cancer organoid | 6 |
| - | 10.6019/CHEMBL5303304 | U2OS | 6 |
| 38516600 | 10.1039/d3md00633f | Glucose-induced degradation protein 4 homolog | 2 |
| 36117290 | 10.1021/acs.jmedchem.2c00509 | Glucose-induced degradation protein 4 homolog | 2 |
| - | 10.6019/CHEMBL5308504 | Cyclin-dependent kinase 2 | 1 |
| - | 10.6019/CHEMBL5308504 | Glycogen synthase kinase-3 beta | 1 |
| - | 10.6019/CHEMBL5308504 | Mitogen-activated protein kinase 1 | 1 |
| - | 10.6019/CHEMBL5308504 | Aurora kinase A | 1 |
| - | 10.6019/CHEMBL5308504 | Tyrosine-protein kinase ABL1 | 1 |
| - | 10.6019/CHEMBL5308504 | Fibroblast growth factor receptor 3 | 1 |
| - | 10.6019/CHEMBL5308504 | Peregrin | 1 |
| - | 10.6019/CHEMBL5308504 | Transcription intermediary factor 1-alpha | 1 |
| - | 10.6019/CHEMBL5308504 | Bromodomain-containing protein 4 | 1 |
| - | 10.6019/CHEMBL5308504 | Casein kinase I isoform delta | 1 |
Data from ChEMBL 36 via Core Engine