Compound Detail
CHEMBL5177923
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CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)C1CCC(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL5177923 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CMVMLPDUAGUTOC-MOXRTSAFSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
2080.2
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gastrin/cholecystokinin type B receptor CHEMBL298 | EC50 | 8.62 | 8.62 | 2.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gastrin/cholecystokinin type B receptor | EC50 | = | 2.4 | nM | 8.62 | Agonist activity at human CCK2R expressed in HEK293 cells assessed as ERK1/2 pho... | 35231829 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35231829 | 10.1016/j.ejmech.2022.114214 | Glucagon-like peptide 1 receptor | 1 |
| 35231829 | 10.1016/j.ejmech.2022.114214 | Cholecystokinin receptor type A | 1 |
| 35231829 | 10.1016/j.ejmech.2022.114214 | Gastrin/cholecystokinin type B receptor | 1 |
Data from ChEMBL 36 via Core Engine