Assay Detail
Toxicity
CHEMBL5146166
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Agonist activity at human CCK2R expressed in HEK293 cells assessed as ERK1/2 phosphorylation incubated for 5 mins by AlphaScreen assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Peptide-based long-acting co-agonists of GLP-1 and cholecystokinin 1 receptors as novel anti-diabesity agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 8.62 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5177923 | — | — | 1 | 8.62 |
| CHEMBL4440419 | — | — | 1 | - |
| CHEMBL5182173 | — | — | 1 | - |
| CHEMBL5185239 | — | — | 1 | - |
| CHEMBL5181266 | — | — | 1 | - |
| CHEMBL5182323 | — | — | 1 | - |
| CHEMBL5182331 | — | — | 1 | - |
| CHEMBL5182775 | — | — | 1 | - |
| CHEMBL410972 | — | — | 1 | - |
| CHEMBL5205878 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5177923 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4440419 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL5182173 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL5185239 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL5181266 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL5182323 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL5182331 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL5182775 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL410972 | — | EC50 | - | — | - | |
| CHEMBL5205878 | — | EC50 | - | — | - |