Compound Detail

CHEMBL5205878

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CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(N)=O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL5205878
Phase	Preclinical
Structure Type	MOL
InChI Key	FYEDXRXIOADMKF-GPCJMOEFSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

3465.8

MW (Da)

Drug Information

Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C155H238N38O52
MW	3465.82

Activity Summary

EC50 1 meas. best 10.25

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Glucagon-like peptide 1 receptor CHEMBL1784	EC50	10.25	10.25	0.1	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Glucagon-like peptide 1 receptor	EC50	=	0.056	nM	10.25	Agonist activity at human GLP-1R expressed in HEK293 cells assessed as cAMP rele...	35231829

Literature References

PubMed	DOI	Target Context	# Activities
35231829	10.1016/j.ejmech.2022.114214	Glucagon-like peptide 1 receptor	1
35231829	10.1016/j.ejmech.2022.114214	Cholecystokinin receptor type A	1
35231829	10.1016/j.ejmech.2022.114214	Gastrin/cholecystokinin type B receptor	1

Data from ChEMBL 36 via Core Engine