Assay Detail
Functional
CHEMBL5146164
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Agonist activity at human GLP-1R expressed in HEK293 cells assessed as cAMP release incubated for 20 min by HTRF analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Peptide-based long-acting co-agonists of GLP-1 and cholecystokinin 1 receptors as novel anti-diabesity agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 9.86 | 10.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205878 | — | — | 1 | 10.25 |
| CHEMBL5182331 | — | — | 1 | 10.13 |
| CHEMBL410972 | — | — | 1 | 10.08 |
| CHEMBL5185239 | — | — | 1 | 10.04 |
| CHEMBL5181266 | — | — | 1 | 9.82 |
| CHEMBL5182173 | — | — | 1 | 9.80 |
| CHEMBL5182775 | — | — | 1 | 9.51 |
| CHEMBL5182323 | — | — | 1 | 9.28 |
| CHEMBL4440419 | — | — | 1 | - |
| CHEMBL5177923 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205878 | — | EC50 | = | 0.056 | nM | 10.25 |
| CHEMBL5182331 | — | EC50 | = | 0.074 | nM | 10.13 |
| CHEMBL410972 | — | EC50 | = | 0.084 | nM | 10.08 |
| CHEMBL5185239 | — | EC50 | = | 0.092 | nM | 10.04 |
| CHEMBL5181266 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL5182173 | — | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL5182775 | — | EC50 | = | 0.31 | nM | 9.51 |
| CHEMBL5182323 | — | EC50 | = | 0.52 | nM | 9.28 |
| CHEMBL4440419 | — | EC50 | - | — | - | |
| CHEMBL5177923 | — | EC50 | - | — | - |