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Compound Detail

CHEMBL518168

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CC(C)Oc1cc(-c2ccc(CCNC[C@H](O)c3cccc(O)c3)cc2)ccc1C(=O)O

Basic Information

ChEMBL ID CHEMBL518168
Phase Preclinical
Structure Type MOL
InChI Key ZZHQCHNBDNTJMG-DEOSSOPVSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

435.5
MW (Da)
4.41
ALogP
5
HBA
4
HBD
99.0
PSA (Ų)
0.35
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H29NO5
MW 435.52
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -0.23

Activity Summary

EC50 2 meas. best 10.21

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 10.21 10.21 0.1 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.36 6.36 440.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18553954 10.1021/jm8000345 Beta-3 adrenergic receptor 2
18553954 10.1021/jm8000345 Unchecked 2
18553954 10.1021/jm8000345 Beta-1 adrenergic receptor 1
18553954 10.1021/jm8000345 Beta-2 adrenergic receptor 1
18553954 10.1021/jm8000345 Canis familiaris 1

Data from ChEMBL 36 via Core Engine