Compound Detail
CHEMBL518644
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C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](C#N)(C3CC3)CC2)cc1)C(F)(F)F
Basic Information
| ChEMBL ID | CHEMBL518644 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GAFZWYWWVFDQDB-BVSLBCMMSA-N |
1
Targets
3
Activities
1
Assay Types
6
PK Parameters
6
Publications
0
Known Names
Molecular Properties
420.5
MW (Da)
4.92
ALogP
3
HBA
1
HBD
64.3
PSA (Ų)
0.74
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL4235 | IC50 | 8.82 | 7.8167 | 1.5 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 4100.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 1000.0 | ng.hr.mL-1 | Macaca fascicularis |
| CL | 3.167 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 1.55 | mL.min-1.kg-1 | Macaca fascicularis |
| F | 40.0 | % | Rattus norvegicus |
| F | 5.0 | % | Macaca fascicularis |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 | IC50 | = | 1.5 | nM | 8.82 | Inhibition of FLAG-tagged full length human 11beta-HSD1 expressed in baculovirus... | 19185488 |
| 11-beta-hydroxysteroid dehydrogenase 1 | IC50 | = | 36.0 | nM | 7.44 | Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cell... | 19185488 |
| 11-beta-hydroxysteroid dehydrogenase 1 | IC50 | = | 64.0 | nM | 7.19 | Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cell... | 19185488 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19185488 | 10.1016/j.bmcl.2009.01.026 | Rattus norvegicus | 4 |
| 19185488 | 10.1016/j.bmcl.2009.01.026 | Cynomolgus monkey | 4 |
| 19185488 | 10.1016/j.bmcl.2009.01.026 | 11-beta-hydroxysteroid dehydrogenase 1 | 3 |
| 19185488 | 10.1016/j.bmcl.2009.01.026 | Liver microsomes | 2 |
| 19185488 | 10.1016/j.bmcl.2009.01.026 | Nuclear receptor subfamily 1 group I member 2 | 1 |
| 19185488 | 10.1016/j.bmcl.2009.01.026 | HeLa | 1 |
Data from ChEMBL 36 via Core Engine