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Compound Detail

CHEMBL5187056

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CCOCCCNC(CO)c1cc(Br)c(N)c(C(F)(F)F)c1.Cl

Basic Information

ChEMBL ID CHEMBL5187056
Phase Preclinical
Structure Type MOL
InChI Key SONANXYUXKGBQC-UHFFFAOYSA-N
Parent Compound CHEMBL5221997
Active Moiety CHEMBL5221997
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

385.2
MW (Da)
3.10
ALogP
4
HBA
3
HBD
67.5
PSA (Ų)
0.48
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H21BrClF3N2O2
MW 421.69
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness -0.70

Activity Summary

EC50 1 meas. best 6.43

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 6.43 6.43 370.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
35360904 10.1021/acs.jmedchem.1c02006 Beta-2 adrenergic receptor 1
35360904 10.1021/acs.jmedchem.1c02006 Beta-1 adrenergic receptor 1
35360904 10.1021/acs.jmedchem.1c02006 Unchecked 1
35360904 10.1021/acs.jmedchem.1c02006 Trachea 1

Data from ChEMBL 36 via Core Engine