Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL5190852

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Cl.Nc1c(Br)cc(C(CO)NC2CCCC2)cc1C(F)(F)F

Basic Information

ChEMBL ID CHEMBL5190852
Phase Preclinical
Structure Type MOL
InChI Key FBMUXNBHXVCLLD-UHFFFAOYSA-N
Parent Compound CHEMBL5222081
Active Moiety CHEMBL5222081
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

367.2
MW (Da)
3.62
ALogP
3
HBA
3
HBD
58.3
PSA (Ų)
0.71
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H19BrClF3N2O
MW 403.67
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness -0.49

Activity Summary

EC50 1 meas. best 7.08

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 7.08 7.08 83.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
35360904 10.1021/acs.jmedchem.1c02006 Beta-2 adrenergic receptor 1
35360904 10.1021/acs.jmedchem.1c02006 Beta-1 adrenergic receptor 1
35360904 10.1021/acs.jmedchem.1c02006 Unchecked 1
35360904 10.1021/acs.jmedchem.1c02006 Trachea 1

Data from ChEMBL 36 via Core Engine