Compound Detail
CHEMBL5191771
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5191771 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | STWMVHZNUMMHCC-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
265.1
MW (Da)
3.33
ALogP
3
HBA
1
HBD
54.5
PSA (Ų)
0.69
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ribosomal protein S6 kinase alpha-5 CHEMBL4237 | IC50 | 7.0 | 5.6667 | 100.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ribosomal protein S6 kinase alpha-5 | IC50 | = | 100.0 | nM | 7.0 | Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to ... | 35859861 |
| Ribosomal protein S6 kinase alpha-5 | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of N-terminal His-Smt-tagged MSK1 C-terminal kinase domain (414 to 73... | 35859861 |
| Ribosomal protein S6 kinase alpha-5 | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of N-terminal His-Smt-tagged MSK1 C-terminal kinase domain (414 to 73... | 35859861 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35859861 | 10.1021/acsmedchemlett.2c00134 | Ribosomal protein S6 kinase alpha-5 | 7 |
Data from ChEMBL 36 via Core Engine