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Compound Detail

CHEMBL5192080

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CCCCCCCCCCCCCC(=O)O[C@H]1CC[C@H]2[C@H]3[C@H]([C@@H](C)C[C@]12C)[C@H]1CCC(=O)C=C1C[C@H]3C

Basic Information

ChEMBL ID CHEMBL5192080
Phase Preclinical
Structure Type MOL
InChI Key VITDUFOVEYKVST-WMLRVYEPSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

512.8
MW (Da)
9.23
ALogP
3
HBA
0
HBD
43.4
PSA (Ų)
0.18
QED
2
Ro5 Violations
13
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H56O3
MW 512.82
Aromatic Rings 0
Heavy Atoms 37
NP-Likeness 1.46

Activity Summary

EC50 1 meas. best 8.32

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Androgen receptor
CHEMBL1871
EC50 8.32 8.32 4.8 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Androgen receptor EC50 = 4.8 nM 8.32 Modulation of Androgen receptor (unknown origin) 35063736

Literature References

PubMed DOI Target Context # Activities
35063736 10.1016/j.ejmech.2022.114119 Androgen receptor 1

Data from ChEMBL 36 via Core Engine