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Compound Detail

CHEMBL519652

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COc1cccc(COCC[N+]23CCC(C(O)(c4ccccc4)c4ccccc4)(CC2)CC3)c1.[Br-]

Basic Information

ChEMBL ID CHEMBL519652
Phase Preclinical
Structure Type MOL
InChI Key ROCIDKGHPSNBKL-UHFFFAOYSA-M
Parent Compound CHEMBL1187765
Active Moiety CHEMBL1187765
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

458.6
MW (Da)
5.15
ALogP
3
HBA
1
HBD
38.7
PSA (Ų)
0.36
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H36BrNO3
MW 538.53
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness -0.14

Activity Summary

Kd 1 meas. best 8.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M3
CHEMBL245
Kd 8.7 8.7 2.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19317446 10.1021/jm801601v Muscarinic acetylcholine receptor M3 2

Data from ChEMBL 36 via Core Engine