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Compound Detail

CHEMBL5203012

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Cc1nc(Nc2cccc(N3CCCCC3=O)n2)sc1-c1cc2c(c(S(=O)(=O)NC3COC3)c1)C(=O)N([C@@H](C)C(F)(F)F)C2

Basic Information

ChEMBL ID CHEMBL5203012
Phase Preclinical
Structure Type MOL
InChI Key ZTXDHUWPUMVZCM-INIZCTEOSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

650.7
MW (Da)
4.36
ALogP
9
HBA
2
HBD
133.8
PSA (Ų)
0.37
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H29F3N6O5S2
MW 650.70
Aromatic Rings 3
Heavy Atoms 44
NP-Likeness -1.30

Activity Summary

IC50 4 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
CHEMBL3130
IC50 9.0 9.0 1.0 1
Unchecked
CHEMBL612545
IC50 8.92 8.92 1.2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
CHEMBL4005
IC50 7.3 7.3 50.0 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
CHEMBL3145
IC50 6.95 6.95 113.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
35569689 10.1016/j.bmcl.2022.128786 No relevant target 2

Data from ChEMBL 36 via Core Engine