Compound Detail
CHEMBL5204319
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CC1(C)CCC(c2ccccc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCN(C(=O)CCCn6cc(COCCOCCNc7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)nn6)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1
Basic Information
| ChEMBL ID | CHEMBL5204319 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OVONRCPOMOIJAO-ADXOFTSBSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1449.7
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein cereblon/Bcl-2-like protein 1 CHEMBL4523705 | EC50 | 7.34 | 7.34 | 46.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein cereblon/Bcl-2-like protein 1 | EC50 | = | 46.0 | nM | 7.34 | PROTAC activity at CRBN/BCL-XL in human WI-38 cells assessed as induction of BCL... | 33160761 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33160761 | 10.1016/j.ejmech.2020.112981 | Protein cereblon/Bcl-2-like protein 1 | 2 |
Data from ChEMBL 36 via Core Engine