Compound Detail
CHEMBL5204795
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Cc1cc(-c2cc3c(=O)n(C)cc(-c4cc(NC(=O)C5CC5)ccc4Oc4ccc(F)cc4F)c3o2)cc(C)c1OCCO
Basic Information
| ChEMBL ID | CHEMBL5204795 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JCHCTCCEOBSGPK-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
600.6
MW (Da)
6.87
ALogP
7
HBA
2
HBD
102.9
PSA (Ų)
0.19
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.49
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain-containing protein 4 CHEMBL1163125 | IC50 | 8.49 | 8.33 | 3.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain-containing protein 4 | IC50 | = | 3.2 | nM | 8.49 | Inhibition of C-terminal His6-tagged BRD4 BD2 (unknown origin) using H-YSGRGK(Ac... | 35333526 |
| Bromodomain-containing protein 4 | IC50 | = | 6.8 | nM | 8.17 | Inhibition of C-terminal His6-tagged BRD4 BD1 (unknown origin) using H-YSGRGK(Ac... | 35333526 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35333526 | 10.1021/acs.jmedchem.2c00100 | Bromodomain-containing protein 4 | 2 |
| 35333526 | 10.1021/acs.jmedchem.2c00100 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine