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Compound Detail

CHEMBL5205059

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CCOc1ccc2c(c1OC(C)C)CCN(c1ccc(C(=O)Nc3cccc(C)n3)cn1)C2

Basic Information

ChEMBL ID CHEMBL5205059
Phase Preclinical
Structure Type MOL
InChI Key QZNKAJSQAZCFDF-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

446.6
MW (Da)
4.79
ALogP
6
HBA
1
HBD
76.6
PSA (Ų)
0.56
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H30N4O3
MW 446.55
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -1.64

Activity Summary

IC50 3 meas. best 6.11

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
HEK-293T
CHEMBL3706568
IC50 6.11 6.11 780.0 1
LNCaP C4-2
CHEMBL4296460
IC50 6.0 6.0 1000.0 1
Unchecked
CHEMBL612545
IC50 6.0 6.0 1000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine