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Compound Detail

CHEMBL5205966

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C[n+]1ccc2cc(-c3ccc(N4C[C@H](CO)OC4=O)cc3F)ccc2c1.[Cl-]

Basic Information

ChEMBL ID CHEMBL5205966
Phase Preclinical
Structure Type MOL
InChI Key IZMBRSYFDYBZBA-UNTBIKODSA-M
Parent Compound CHEMBL5222813
Active Moiety CHEMBL5222813
2
Targets
7
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

353.4
MW (Da)
2.79
ALogP
3
HBA
1
HBD
53.6
PSA (Ų)
0.74
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H18ClFN2O3
MW 388.83
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -0.34

Activity Summary

IC50 7 meas. best 5.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Escherichia coli
CHEMBL354
IC50 5.4 4.765 4000.0 4
Acinetobacter baumannii
CHEMBL614425
IC50 4.7 4.5933 20100.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
36257060 10.1021/acs.jmedchem.2c01349 Acinetobacter baumannii 4
36257060 10.1021/acs.jmedchem.2c01349 Escherichia coli 4
36257060 10.1021/acs.jmedchem.2c01349 Pseudomonas aeruginosa 4

Data from ChEMBL 36 via Core Engine