Assay Detail
Functional
CHEMBL5107403
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Antibacterial activity against recombinant OM pore producing Escherichia coli assessed as inhibition of bacterial growth
80
Total Activities
80
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Uptake Relationship Studies of Oxazolidinones in Gram-Negative ESKAPE Pathogens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 80 | 4.81 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174558 | — | — | 1 | 5.92 |
| CHEMBL5189056 | — | — | 1 | 5.82 |
| CHEMBL5183837 | — | — | 1 | 5.77 |
| CHEMBL5202385 | — | — | 1 | 5.70 |
| CHEMBL5173883 | — | — | 1 | 5.70 |
| CHEMBL5201079 | — | — | 1 | 5.62 |
| CHEMBL5179408 | — | — | 1 | 5.58 |
| CHEMBL5186560 | — | — | 1 | 5.50 |
| CHEMBL5176762 | — | — | 1 | 5.47 |
| CHEMBL5197931 | — | — | 1 | 5.40 |
| CHEMBL5180857 | — | — | 1 | 5.33 |
| CHEMBL5179367 | — | — | 1 | 5.30 |
| CHEMBL5202730 | — | — | 1 | 5.25 |
| CHEMBL5197646 | — | — | 1 | 5.12 |
| CHEMBL5196659 | — | — | 1 | 5.11 |
| CHEMBL5204810 | — | — | 1 | 5.03 |
| CHEMBL5180592 | — | — | 1 | 4.91 |
| CHEMBL5175197 | — | — | 1 | 4.89 |
| CHEMBL5209470 | — | — | 1 | 4.88 |
| CHEMBL5178366 | — | — | 1 | 4.84 |
| CHEMBL126 | LINEZOLID | 4.0 | 1 | 4.75 |
| CHEMBL5181450 | — | — | 1 | 4.75 |
| CHEMBL5180722 | — | — | 1 | 4.72 |
| CHEMBL5209101 | — | — | 1 | 4.71 |
| CHEMBL5193767 | — | — | 1 | 4.69 |
| CHEMBL5195057 | — | — | 1 | 4.68 |
| CHEMBL5206466 | — | — | 1 | 4.67 |
| CHEMBL5208917 | — | — | 1 | 4.66 |
| CHEMBL5205866 | — | — | 1 | 4.64 |
| CHEMBL5179818 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174558 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5189056 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5183837 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5202385 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5173883 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5201079 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5179408 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5186560 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5176762 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5197931 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5180857 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5179367 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5202730 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5197646 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5196659 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5204810 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5180592 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL5175197 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL5209470 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL5178366 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL126 | LINEZOLID | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5181450 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL5180722 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL5209101 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL5193767 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL5195057 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL5206466 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL5208917 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL5205866 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL5179818 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL5206342 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL5185157 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL5200772 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL5205966 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL5184232 | — | IC50 | = | 35100.0 | nM | 4.46 |
| CHEMBL5190226 | — | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL5184902 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL5180265 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL5193973 | — | IC50 | = | 42800.0 | nM | 4.37 |
| CHEMBL5205131 | — | IC50 | = | 44400.0 | nM | 4.35 |
| CHEMBL5185676 | — | IC50 | = | 46300.0 | nM | 4.33 |
| CHEMBL5175286 | — | IC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL5172381 | — | IC50 | = | 51400.0 | nM | 4.29 |
| CHEMBL5192651 | — | IC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL5173353 | — | IC50 | = | 56100.0 | nM | 4.25 |
| CHEMBL5209375 | — | IC50 | = | 56100.0 | nM | 4.25 |
| CHEMBL5173025 | — | IC50 | = | 61500.0 | nM | 4.21 |
| CHEMBL5191488 | — | IC50 | = | 65300.0 | nM | 4.18 |
| CHEMBL5202779 | — | IC50 | = | 74300.0 | nM | 4.13 |
| CHEMBL5190363 | — | IC50 | = | 76900.0 | nM | 4.11 |