Compound Detail
CHEMBL5207143
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CCS(=O)(=O)Nc1ccc(Oc2c(OC)cccc2OC)c(-c2cn(C)c(=O)c3cc(-c4cc(C)c(OCCO)c(C)c4)oc23)c1
Basic Information
| ChEMBL ID | CHEMBL5207143 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NNMQMUMEXHIKFW-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
648.7
MW (Da)
6.02
ALogP
10
HBA
2
HBD
138.5
PSA (Ų)
0.17
QED
2
Ro5 Violations
12
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain-containing protein 4 CHEMBL1163125 | IC50 | 8.7 | 8.355 | 2.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain-containing protein 4 | IC50 | = | 2.0 | nM | 8.7 | Inhibition of C-terminal His6-tagged BRD4 BD2 (unknown origin) using H-YSGRGK(Ac... | 35333526 |
| Bromodomain-containing protein 4 | IC50 | = | 9.8 | nM | 8.01 | Inhibition of C-terminal His6-tagged BRD4 BD1 (unknown origin) using H-YSGRGK(Ac... | 35333526 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35333526 | 10.1021/acs.jmedchem.2c00100 | Bromodomain-containing protein 4 | 2 |
| 35333526 | 10.1021/acs.jmedchem.2c00100 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine