Compound Detail
CHEMBL5208317
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Basic Information
| ChEMBL ID | CHEMBL5208317 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SCPUCWVMRBQJLW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
426.9
MW (Da)
5.31
ALogP
4
HBA
2
HBD
72.2
PSA (Ų)
0.45
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.45
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | Ki | 6.45 | 6.45 | 359.1 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1B CHEMBL5543 | Ki | 5.36 | 5.36 | 4398.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Ki | = | 359.1 | nM | 6.45 | Inhibition of human DYRK1A incubated for 90 mins in presence of ATP by Z-LYTE ba... | 35504513 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Ki | = | 4398.7 | nM | 5.36 | Inhibition of human DYRK1B incubated for 130 mins in presence of ATP by ADP-Glo ... | 35504513 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35504513 | 10.1016/j.bmcl.2022.128764 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
| 35504513 | 10.1016/j.bmcl.2022.128764 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | 1 |
Data from ChEMBL 36 via Core Engine