Compound Detail
CHEMBL5208814
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Basic Information
| ChEMBL ID | CHEMBL5208814 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NDHVOUMIKBJAQL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
219.3
MW (Da)
2.24
ALogP
3
HBA
0
HBD
29.5
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.94
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B CHEMBL311 | Ki | 6.94 | 6.94 | 113.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B | Ki | = | 113.87 | nM | 6.94 | Displacement of [3H]ifenprodil from rat GluN2B assessed as inhibition constant m... | 38413367 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38413367 | 10.1021/acs.jmedchem.3c01524 | Rattus norvegicus | 11 |
| 34710748 | 10.1016/j.ejmech.2021.113876 | Unchecked | 3 |
| 38413367 | 10.1021/acs.jmedchem.3c01524 | Glutamate receptor ionotropic, NMDA 2B | 1 |
| 38413367 | 10.1021/acs.jmedchem.3c01524 | Glutamate NMDA receptor; GRIN1/GRIN2B | 1 |
| 38413367 | 10.1021/acs.jmedchem.3c01524 | Neuron | 1 |
| 38413367 | 10.1021/acs.jmedchem.3c01524 | ADMET | 1 |
| 38413367 | 10.1021/acs.jmedchem.3c01524 | L929 | 1 |
| 38413367 | 10.1021/acs.jmedchem.3c01524 | HEK293 | 1 |
Data from ChEMBL 36 via Core Engine