Compound Detail
CHEMBL5219044
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5219044 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PCRMCHSDFBNDLX-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
473.9
MW (Da)
2.87
ALogP
5
HBA
2
HBD
110.3
PSA (Ų)
0.55
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Complement factor D CHEMBL2176771 | IC50 | 5.26 | 5.18 | 5500.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Complement factor D | IC50 | = | 5500.0 | nM | 5.26 | Inhibition Assay: An established esterolytic assay for the measurement of Factor... | - |
| Complement factor D | IC50 | = | 5500.0 | nM | 5.26 | Factor D Esterolytic Assay: An established esterolytic assay for the measurement... | - |
| Complement factor D | IC50 | = | 9500.0 | nM | 5.02 | Inhibition of human complement factor D using Z-L-Lys-SBzl hydrochloride as subs... | 36272185 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36272185 | 10.1016/j.bmc.2022.117034 | Complement factor D | 1 |
| 36272185 | 10.1016/j.bmc.2022.117034 | Erythrocyte | 1 |
Data from ChEMBL 36 via Core Engine