Compound Detail
CHEMBL523741
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Basic Information
| ChEMBL ID | CHEMBL523741 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LHHCZOUDWJLWHD-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
328.4
MW (Da)
3.34
ALogP
5
HBA
1
HBD
73.8
PSA (Ų)
0.61
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mast/stem cell growth factor receptor Kit CHEMBL1936 | IC50 | 6.68 | 6.68 | 210.0 | 1 |
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 6.0 | 6.0 | 990.0 | 1 |
| Tyrosine-protein kinase Lck CHEMBL258 | IC50 | 5.77 | 5.77 | 1700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mast/stem cell growth factor receptor Kit | IC50 | = | 210.0 | nM | 6.68 | Inhibition of c-Kit by TR-FRET assay | 18447379 |
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 990.0 | nM | 6.0 | Inhibition of Src by TR-FRET assay | 18447379 |
| Tyrosine-protein kinase Lck | IC50 | = | 1700.0 | nM | 5.77 | Inhibition of Lck by TR-FRET assay | 18447379 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18447379 | 10.1021/jm800188g | Mast/stem cell growth factor receptor Kit | 1 |
| 18447379 | 10.1021/jm800188g | Vascular endothelial growth factor receptor 2 | 1 |
| 18447379 | 10.1021/jm800188g | Tyrosine-protein kinase Lck | 1 |
| 18447379 | 10.1021/jm800188g | Proto-oncogene tyrosine-protein kinase Src | 1 |
Data from ChEMBL 36 via Core Engine