Compound Detail
CHEMBL524631
HYACINTHACINE B3 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL524631 |
| Name | HYACINTHACINE B3 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PIBHCJDPQRCONN-MVEQLIQHSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
203.2
MW (Da)
-2.09
ALogP
5
HBA
4
HBD
84.2
PSA (Ų)
0.39
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lactase/phlorizin hydrolase CHEMBL3389 | IC50 | 4.75 | 4.75 | 18000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.29 | 4.29 | 51000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lactase/phlorizin hydrolase | IC50 | = | 18000.0 | nM | 4.75 | Inhibition of rat intestinal lactase assessed as p-nitrophenol release after 30 ... | 12502331 |
| Unchecked | IC50 | = | 51000.0 | nM | 4.29 | Inhibition of rat intestinal amyloglucosidase | 12502331 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12502331 | 10.1021/np020296h | Unchecked | 3 |
| 12502331 | 10.1021/np020296h | Acidic alpha-glucosidase | 2 |
| 12502331 | 10.1021/np020296h | Lactase/phlorizin hydrolase | 1 |
| 12502331 | 10.1021/np020296h | Tissue alpha-L-fucosidase | 1 |
| 12502331 | 10.1021/np020296h | Beta-galactosidase | 1 |
| 12502331 | 10.1021/np020296h | Beta-glucosidase A | 1 |
| 12502331 | 10.1021/np020296h | Oligo-1,6-glucosidase IMA1 | 1 |
Data from ChEMBL 36 via Core Engine