Compound Detail
CHEMBL525610
TERIPARATIDE 💊 Approved Drug
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💊 Approved Drug
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C
Basic Information
| ChEMBL ID | CHEMBL525610 |
| Name | TERIPARATIDE |
| Phase | Approved |
| Structure Type | BOTH |
| InChI Key | OGBMKVWORPGQRR-UMXFMPSGSA-N |
| Therapeutic | ✓ Yes |
1
Targets
4
Activities
2
Assay Types
8
PK Parameters
10
Publications
22
Known Names
12
Indications
1
Mechanisms
Molecular Properties
4117.8
MW (Da)
Drug Information
| Molecule Type | Protein |
| First Approval | 2002 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Parathyroid hormone receptor agonist | AGONIST | Parathyroid hormone/parathyroid hormone-related peptide receptor | ✓ | ✓ |
Indications
Osteoporosis Osteoporosis, Postmenopausal Back Pain Bone Diseases, Metabolic Fractures, Bone Hip Fractures Arthropathy, Neurogenic Hypocalcemia Hypoparathyroidism Osteoarthritis, Knee Osteogenesis Imperfecta Radius Fractures
ATC Classification
H05AA02
teriparatide
Level 1: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
Level 2: CALCIUM HOMEOSTASIS
Drug Warnings
Black Box Warning
carcinogenicity
Activity Summary
EC50 3 meas. best 9.52
IC50 1 meas. best 10.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Parathyroid hormone/parathyroid hormone-related peptide receptor CHEMBL1793 | IC50 | 10.1 | 10.1 | 0.1 | 1 |
| Parathyroid hormone/parathyroid hormone-related peptide receptor CHEMBL1793 | EC50 | 9.52 | 9.04 | 0.3 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 62.0 | L/hr | Homo sapiens |
| CL | 94.0 | L/hr | Homo sapiens |
| F | 95.0 | % | Homo sapiens |
| T1/2 | 0.5 | hr | Rattus norvegicus |
| T1/2 | 1.0 | hr | Homo sapiens |
| Tmax | 0.5 | hr | Homo sapiens |
| Tmax | 0.25 | hr | Rattus norvegicus |
| Vd | 0.12 | L.kg-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19492813 | 10.1021/jm900364m | Homo sapiens | 4 |
| 29932656 | 10.1021/acs.jmedchem.8b00182 | Rattus norvegicus | 4 |
| 38717088 | 10.1021/acs.jmedchem.4c00349 | Mus musculus | 4 |
| 29932656 | 10.1021/acs.jmedchem.8b00182 | Parathyroid hormone/parathyroid hormone-related peptide receptor | 3 |
| 19932972 | 10.1016/j.bmc.2009.11.002 | Unchecked | 2 |
| 20218623 | 10.1021/jm9018756 | Parathyroid hormone/parathyroid hormone-related peptide receptor | 2 |
| 26948801 | 10.1016/j.drudis.2016.02.015 | Homo sapiens | 2 |
| 38691890 | 10.1016/j.ejmech.2024.116456 | ADMET | 2 |
| 31257875 | 10.1021/acs.jmedchem.9b00270 | MC3T3-E1 | 1 |
| 38717088 | 10.1021/acs.jmedchem.4c00349 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine