Compound Detail
CHEMBL52640
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Basic Information
| ChEMBL ID | CHEMBL52640 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FWZBUGMDRBQDHJ-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
382.4
MW (Da)
4.53
ALogP
6
HBA
0
HBD
61.5
PSA (Ų)
0.45
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 7.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; alpha-3/beta-3/gamma-2 CHEMBL2094120 | Ki | 7.18 | 7.18 | 66.0 | 1 |
| GABA-A receptor; alpha-5/beta-3/gamma-2 CHEMBL2094122 | Ki | 6.82 | 6.82 | 150.0 | 1 |
| GABA-A receptor; alpha-2/beta-3/gamma-2 CHEMBL2094130 | Ki | 6.77 | 6.77 | 170.0 | 1 |
| GABA-A receptor; alpha-1/beta-3/gamma-2 CHEMBL2094121 | Ki | 6.1 | 6.1 | 800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; alpha-3/beta-3/gamma-2 | Ki | = | 66.0 | nM | 7.18 | Binding affinity for human GABA-A receptor alpha-3-beta-3-gamma-2 subunits in L(... | 15027873 |
| GABA-A receptor; alpha-5/beta-3/gamma-2 | Ki | = | 150.0 | nM | 6.82 | Binding affinity for human GABA-A receptor alpha-5-beta-3-gamma-2 subunits in L(... | 15027873 |
| GABA-A receptor; alpha-2/beta-3/gamma-2 | Ki | = | 170.0 | nM | 6.77 | Binding affinity for human GABA-A receptor alpha-2-beta-3-gamma-2 subunits in L(... | 15027873 |
| GABA-A receptor; alpha-1/beta-3/gamma-2 | Ki | = | 800.0 | nM | 6.1 | Binding affinity for human GABA-A receptor alpha-4-beta-3-gamma-2 subunits in L(... | 15027873 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15027873 | 10.1021/jm031020p | GABA-A receptor; alpha-1/beta-3/gamma-2 | 1 |
| 15027873 | 10.1021/jm031020p | GABA-A receptor; alpha-2/beta-3/gamma-2 | 1 |
| 15027873 | 10.1021/jm031020p | GABA-A receptor; alpha-3/beta-3/gamma-2 | 1 |
| 15027873 | 10.1021/jm031020p | GABA-A receptor; alpha-5/beta-3/gamma-2 | 1 |
Data from ChEMBL 36 via Core Engine