Compound Detail
CHEMBL5268216
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Basic Information
| ChEMBL ID | CHEMBL5268216 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OUYDLIURZBBDPT-IJLIMOAPSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
368.5
MW (Da)
3.19
ALogP
3
HBA
1
HBD
58.6
PSA (Ų)
0.89
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Monoglyceride lipase CHEMBL4191 | IC50 | 9.68 | 9.68 | 0.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Monoglyceride lipase | IC50 | = | 0.21 | nM | 9.68 | Inhibition of MGL activity in human HeLa cells assessed as reduction in cleaved ... | 37197472 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37197472 | 10.1021/acsmedchemlett.3c00121 | Monoglyceride lipase | 1 |
Data from ChEMBL 36 via Core Engine