Compound Detail
CHEMBL5268653
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COc1ccc([C@H](C)N2CC(=O)N[C@H](C)C(=O)N(CCc3ccccc3Oc3ccccc3)CC(=O)N(c3cc(OC)cc(OC)c3)CC(=O)N(CCCOC(C)C)CC(=O)N([C@@H](C)c3ccc(OC)cc3)CC2=O)cc1
Basic Information
| ChEMBL ID | CHEMBL5268653 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QNURSWNKRAWMEW-PYHIYFCPSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1057.3
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.98
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.98 | 6.98 | 105.0 | 1 |
| Catenin beta-1/Transcription factor 7 CHEMBL3885542 | IC50 | 5.26 | 5.26 | 5440.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 105.0 | nM | 6.98 | Inhibition of full length GST-tagged Wnt (unknown origin) by luciferase assay | 32871340 |
| Catenin beta-1/Transcription factor 7 | IC50 | = | 5440.0 | nM | 5.26 | Inhibition of N-terminal beta-catenin/full length myc-tagged TCF (unknown origin... | 32871340 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32871340 | 10.1016/j.ejmech.2020.112764 | Unchecked | 1 |
| 32871340 | 10.1016/j.ejmech.2020.112764 | Catenin beta-1/Transcription factor 7 | 1 |
Data from ChEMBL 36 via Core Engine