Compound Detail
CHEMBL5273706
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CC(C)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O
Basic Information
| ChEMBL ID | CHEMBL5273706 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YQZCVINPOZDEDZ-YXDRAXQRSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1511.6
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 CHEMBL5023 | IC50 | 7.36 | 7.36 | 44.0 | 1 |
| Protein Mdm4 CHEMBL1255126 | IC50 | 6.26 | 6.26 | 550.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 | IC50 | = | 44.0 | nM | 7.36 | Inhibition of human MDM2 by ELISA assay | 34286973 |
| Protein Mdm4 | IC50 | = | 550.0 | nM | 6.26 | Inhibition of human MDM4 by ELISA assay | 34286973 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34286973 | 10.1021/acs.jmedchem.1c00940 | Protein Mdm4 | 1 |
| 34286973 | 10.1021/acs.jmedchem.1c00940 | E3 ubiquitin-protein ligase Mdm2 | 1 |
Data from ChEMBL 36 via Core Engine