Compound Detail
CHEMBL5275918
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C=CC(=O)N1CC[C@H](n2nc(C(=O)Nc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1
Basic Information
| ChEMBL ID | CHEMBL5275918 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HZLLOAHTNOGYBJ-ZDUSSCGKSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
437.5
MW (Da)
1.64
ALogP
9
HBA
2
HBD
137.5
PSA (Ų)
0.56
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 6.17 | 6.17 | 670.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 | IC50 | = | 670.0 | nM | 6.17 | Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) inc... | 37077386 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37077386 | 10.1021/acsmedchemlett.3c00006 | Fibroblast growth factor receptor 2 | 1 |
| 37077386 | 10.1021/acsmedchemlett.3c00006 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine